11/10/2023 0 Comments Myelin oligodendrocyte glycoproteinKey testing considerations for these antibodies are summarized in Table 1. cerebrospinal fluid (CSF) testing, and the value of antibody titers in diagnostic interpretation of results. We herein discuss test methodologies used to detect these antibodies, the role of serum vs. Recognition of their substantial impact on patient diagnosis and management has led to a dramatic increase in testing for these antibodies among patients with suspected autoimmune myelopathy, which parallels an increase in neural antibody testing for suspected neurological autoimmunity more generally ( 18– 20). Antibodies targeting aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) define disease processes that can cause immune-mediated spinal cord dysfunction and have clinical features, treatment considerations and prognoses distinct from multiple sclerosis (MS) ( 1– 17). cerebrospinal fluid testing, and the value of antibody titers when interpreting results, with the aim of helping laboratorians and clinicians navigate this testing when ordered as part of the diagnostic evaluation for suspected autoimmune myelopathy.Īutoimmune myelopathies are immune-mediated disorders of the spinal cord that can cause profound weakness, numbness, and bowel/bladder dysfunction. In this review we discuss test methodologies used to detect these antibodies, the role of serum vs. The detection of these antibodies can substantially impact patient diagnosis and management, and increasing awareness of this has led to a dramatic increase in testing for these antibodies among patients with suspected autoimmune myelopathy. Discoveries of antibodies targeting aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) have facilitated the diagnosis of autoimmune myelopathies that were previously considered to be atypical presentations of multiple sclerosis (MS) or idiopathic, and represent major advancements in the field of autoimmune neurology. Autoimmune myelopathies are immune-mediated disorders of the spinal cord that can cause significant neurologic disability.
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